Poor oral health conditions and cognitive decline: Studies in humans and rats.

ABSTRACT: BACKGROUND:The relationship between poor oral health conditions and cognitive decline is unclear. OBJECTIVE:To examine the association between oral health and cognition in humans and rats. METHODS:In humans: a cross-sectional study was conducted. Cognitive levels were evaluated by the Mini Mental State Examination (MMSE); oral conditions were reflected by the number of missing index teeth, bleeding on probing, and probing pocket depth (PD). In rats: a ligature-induced (Lig) periodontitis model and Aβ25-35-induced model of Alzheimer's disease (AD) were established; tumor necrosis factor-α (TNF-α), interleukin 1 (IL-1), interleukin 6 (IL-6), and C-reactive protein levels in the hippocampus and cerebral cortex were detected. RESULTS:MMSE scores for the number of missing index teeth ≥ 7 group

SUBMITTER: Zhang S 

PROVIDER: S-EPMC7332063 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature