Identification of FABP5 as an immunometabolic marker in human hepatocellular carcinoma.

ABSTRACT:

Background

Regulating T-cell metabolism is crucial for their anticancer activity. Therefore, understanding the function and metabolism of human tumor-infiltrating T cells is of broad interest and clinical importance.

Methods

CD3⁺CD45⁺ T cells were sorted from adjacent area or tumor core of human hepatocellular carcinoma (HCC), then the clusters and heterogeneity of T cells were further interrogated by single-cell transcriptomic profiling. 118 surgical samples from patients with HCC were histologically examined for infiltration of CD8⁺ T cells in tumor and adjacent tissue.

Results

Single-cell transcriptomic profiling indicated that several exhausted T-cell (Tex) populations differentially coexisted in the tumor and adjacent tissue. CD13

SUBMITTER: Liu F 

PROVIDER: S-EPMC7332195 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature