Genomic and clinical characterization of stromal infiltration markers in prostate cancer.

ABSTRACT:

Background

The progression of prostate cancer is a complex, multistep process that involves molecular alterations in cells of the tumor and the microenvironment, with associated interactions between the stroma and epithelium. Genomic expression analyses of stromal infiltration markers were performed to determine the significance thereof in prostate cancer.

Methods

Genome-wide expression profiles of formalin-fixed, paraffin-embedded radical prostatectomy samples were evaluated from a prospective registry cohort (n = 5239) and 3 retrospective institutional cohorts (n = 1135). Two independent stromal gene expression signatures implied stromal infiltration. Cox proportional hazards regression defined the association between stromal infiltration expression and metastasis-free sur

SUBMITTER: Mahal BA 

PROVIDER: S-EPMC7332205 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature