A variant near DHCR24 associates with microstructural properties of white matter and peripheral lipid metabolism in adolescents.

ABSTRACT: Visceral adiposity has been associated with altered microstructural properties of white matter in adolescents. Previous evidence suggests that circulating phospholipid PC(16:0/2:0) may mediate this association. To investigate the underlying biology, we performed a genome-wide association study (GWAS) of the shared variance of visceral fat, PC(16:0/2:0), and white matter microstructure in 872 adolescents from the Saguenay Youth Study. We further studied the metabolomic profile of the GWAS-lead variant in 931 adolescents. Visceral fat and white matter microstructure were assessed with magnetic resonance imaging. Circulating metabolites were quantified with serum lipidomics and metabolomics. We identified a genome-wide significant association near DHCR24 (Seladin-1) encoding a cholesterol-syn

SUBMITTER: Sliz E 

PROVIDER: S-EPMC7332371 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature