Time-delimited signaling of MET receptor tyrosine kinase regulates cortical circuit development and critical period plasticity.

ABSTRACT: Normal development of cortical circuits, including experience-dependent cortical maturation and plasticity, requires precise temporal regulation of gene expression and molecular signaling. Such regulation, and the concomitant impact on plasticity and critical periods, is hypothesized to be disrupted in neurodevelopmental disorders. A protein that may serve such a function is the MET receptor tyrosine kinase, which is tightly regulated developmentally in rodents and primates, and exhibits reduced cortical expression in autism spectrum disorder and Rett Syndrome. We found that the peak of MET expression in developing mouse cortex coincides with the heightened period of synaptogenesis, but is precipitously downregulated prior to extensive synapse pruning and certain peak periods of cortical p

SUBMITTER: Chen K 

PROVIDER: S-EPMC7332377 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature