Neural Insensitivity to the Effects of Hunger in Women Remitted From Anorexia Nervosa.

ABSTRACT:

Objective

Anorexia nervosa has the highest mortality rate of any psychiatric condition, yet the pathophysiology of this disorder and its primary symptom, extreme dietary restriction, remains poorly understood. In states of hunger relative to satiety, the rewarding value of food stimuli normally increases to promote eating, yet individuals with anorexia nervosa avoid food despite emaciation. This study's aim was to examine potential neural insensitivity to these effects of hunger in anorexia nervosa.

Methods

At two scanning sessions scheduled 24 hours apart, one after a 16-hour fast and one after a standardized meal, 26 women who were in remission from anorexia nervosa (to avoid the confounding effects of malnutrition) and 22 matched control women received tastes of sucrose s

SUBMITTER: Kaye WH 

PROVIDER: S-EPMC7332383 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature