Uncovering Biological Factors That Regulate Hepatocellular Carcinoma Growth Using Patient-Derived Xenograft Assays.

ABSTRACT:

Background and aims

Several major factors limit our understanding of hepatocellular carcinoma (HCC). First, human HCCs are infrequently biopsied for diagnosis and thus are not often biologically interrogated. Second, HCC initiation and progression are strongly influenced by the cirrhotic microenvironment, and the exact contributions of intrinsic and extrinsic tumor factors are unclear. A powerful approach to examine the personalized biology of liver cancers and the influence of host tissues is with patient-derived xenograft (PDX) models. In Asia, HCCs from patients with hepatitis B virus have been efficiently converted into PDXs, but few parallel efforts from the west have been reported.

Approach and results

In a large-scale analysis, we implanted 93 HCCs and 8 cholangiocarc

SUBMITTER: Zhu M 

PROVIDER: S-EPMC7332388 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature