Predictors of cognitive development in children with neurofibromatosis type 1 and plexiform neurofibromas.

ABSTRACT:

Aim

To describe the cognitive development of children with neurofibromatosis type 1 (NF1) and plexiform neurofibromas, and identify predictors of cognitive development.

Method

Participants included 88 children with NF1 and plexiform neurofibromas (50 males, 38 females, aged 6-18y, mean=12y, SD=3y 7mo) on a natural history study at the National Cancer Institute. Neuropsychological assessments (e.g. IQ, academic achievement, attention, and executive functioning) were administered three times over 6 years.

Results

Relative to normative peers, the total sample of children with NF1 and plexiform neurofibromas demonstrated significantly lower scores in most cognitive domains and decreasing z-scores over time in math, writing, inhibitory control, and working memory. Children

SUBMITTER: Hou Y 

PROVIDER: S-EPMC7332409 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature