Patient-specific heart simulation can identify non-responders to cardiac resynchronization therapy.

ABSTRACT: To identify non-responders to cardiac resynchronization therapy (CRT), various biomarkers have been proposed, but these attempts have not been successful to date. We tested the clinical applicability of computer simulation of CRT for the identification of non-responders. We used the multi-scale heart simulator "UT-Heart," which can reproduce the electrophysiology and mechanics of the heart based on a molecular model of the excitation-contraction mechanism. Patient-specific heart models were created for eight heart failure patients who were treated with CRT, based on the clinical data recorded before treatment. Using these heart models, bi-ventricular pacing simulations were performed at multiple pacing sites adopted in clinical practice. Improvement in pumping function measured by the rela

SUBMITTER: Isotani A 

PROVIDER: S-EPMC7332486 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature