Comprehensive Analysis of the PD-L1 and Immune Infiltrates of m⁶A RNA Methylation Regulators in Head and Neck Squamous Cell Carcinoma.

ABSTRACT: Because most studies have focused on the intrinsic carcinogenic pathways of tumors, the underlying role of N6-methyladenosine (m⁶A) methylation in tumor immune microenvironment (TIME) remains elusive. Herein, we systematically explored the correlations of prominent m⁶A regulators with PD-L1 and immune infiltrates in 769 head and neck squamous cell carcinomas (HNSCCs; The Cancer Genome Atlas [TCGA] cohort, n = 499; GSE65858 cohort, n = 270). The PD-L1 expression evidently associated with m⁶A regulators. Two molecular subtypes (cluster1/2) were identified by consensus clustering for 15 m⁶A regulators. The cluster2 preferentially associated with favorable prognosis, upregulated PD-L1 expression, higher immunoscore, and distinct immune cell infiltrat

SUBMITTER: Yi L 

PROVIDER: S-EPMC7332506 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature