The neural stem-cell marker CD24 is specifically upregulated in IDH-mutant glioma.

ABSTRACT:

Background

Malignant gliomas have disproportionally high morbidity and mortality. Heterozygous mutations in the isocitrate dehydrogenase 1 (IDH1) gene are most common in glioma, resulting in predominantly arginine to histidine substitution at codon 132. Because IDH1^R132H requires a wild-type allele to produce (D)-2-hydroxyglutarate for epigenetic reprogramming, loss of IDH1^R132H heterozygosity is associated with glioma progression in an IDH1-wildtype-like phenotype. Although previous studies have reported that transgenic IDH1^R132H induces the expression of nestin-a neural stem-cell marker, the underlying mechanism remains unclear. Furthermore, this finding seems at odds with better outcome of IDH1^R132H glioma because of a negative associa

SUBMITTER: Tiburcio PDB 

PROVIDER: S-EPMC7332530 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature