Causes and characteristics of death in patients with acute hypoxemic respiratory failure and acute respiratory distress syndrome: a retrospective cohort study.

ABSTRACT:

Background

Acute hypoxemic respiratory failure (AHRF) and acute respiratory distress syndrome (ARDS) are associated with high in-hospital mortality. However, in cohorts of ARDS patients from the 1990s, patients more commonly died from sepsis or multi-organ failure rather than refractory hypoxemia. Given increased attention to lung-protective ventilation and sepsis treatment in the past 25 years, we hypothesized that causes of death may be different among contemporary cohorts. These differences may provide clinicians with insight into targets for future therapeutic interventions.

Methods

We identified adult patients hospitalized at a single tertiary care center (2016-2017) with AHRF, defined as PaO₂/FiO₂ ≤ 300 while receiving invasive mechanical ventilat

SUBMITTER: Ketcham SW 

PROVIDER: S-EPMC7332537 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature