Management of Secondary Genomic Findings.

ABSTRACT: Secondary genomic findings are increasingly being returned to individuals as opportunistic screening results. A secondary finding offers the chance to identify and mitigate disease that may otherwise be unrecognized in an individual. As a form of screening, secondary findings must be considered differently from sequencing results in a diagnostic setting. For these reasons, clinicians should employ an evaluation and long-term management strategy that accounts for both the increased disease risk associated with a secondary finding and the lower positive predictive value of a screening result compared to an indication-based testing result. Here we describe an approach to the clinical evaluation and management of an individual who presents with a secondary finding. This approach enumerates fiv

SUBMITTER: Katz AE 

PROVIDER: S-EPMC7332641 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature