Arsenic trioxide induces regulatory functions of plasmacytoid dendritic cells through interferon- α inhibition.

ABSTRACT: Arsenic trioxide (As₂O₃) is recently found to have therapeutic potential in systemic sclerosis (SSc), a life-threatening multi-system fibrosing autoimmune disease with type I interferon (IFN-I) signature. Chronically activated plasmacytoid dendritic cells (pDCs) are responsible for IFN-I secretion and are closely related with fibrosis establishment in SSc. In this study, we showed that high concentrations of As₂O₃ induced apoptosis of pDCs via mitochondrial pathway with increased BAX/BCL-2 ratio, while independent of reactive oxygen species generation. Notably, at clinical relevant concentrations, As₂O₃ preferentially inhibited IFN-α secretion as compared to other cytokines such as TNF-α, probably due to

SUBMITTER: Ye Y 

PROVIDER: S-EPMC7332672 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature