Functional Connectivity Abnormalities of Brain Regions With Structural Deficits in Primary Insomnia Patients.

ABSTRACT:

Objectives

The present study examined the abnormal resting state functional connections (RSFCs) in structural deficit brain regions of primary insomnia (PI) patients.

Methods

Thirty-three PI patients and 38 well-matched healthy controls participated in our study. We used voxel-based morphometry and RSFC to study functional connectivity abnormalities of brain regions with structural deficits in PI patients.

Results

PI patients showed decreased gray matter (GM) volume in the left dorsolateral prefrontal cortex, left orbitofrontal cortex (OFC), bilateral middle frontal gyrus (MFC), right inferior frontal gyrus (IFG), and left inferior temporal gyrus. Gray matter volume in the right MFC negatively correlated with Self-Rating Scale of Sleep (SRSS) scores, and GM volume in

SUBMITTER: Xie D 

PROVIDER: S-EPMC7332723 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature