Identification of a Human <i>SOCS1</i> Polymorphism That Predicts Rheumatoid Arthritis Severity.

ABSTRACT: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by an autoimmune response in the joints and an exacerbation of cytokine responses. A minority of patients with RA experience spontaneous remission, but most will show moderate/high disease activity, with aggressive joint damage and multiple systemic manifestations. There is thus is a great need to identify prognostic biomarkers for disease risk to improve diagnosis and prognosis, and to inform on the most appropriate therapy. Here we focused on suppressor of cytokine signaling 1 (SOCS1), a physiological negative regulator of cytokines that modulates cell activation. Using four independent cohorts of patients with arthritis, we characterized the correlation between SOCS1 mRNA levels and clinical outcome. We fou

SUBMITTER: Lamana A 

PROVIDER: S-EPMC7332777 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature