Antinociceptive grayanane-derived diterpenoids from flowers of Rhododendron molle.

ABSTRACT: Twelve new grayanoids (1-12) along with five known compounds were isolated from flowers of Rhododendron molle. Their structures were fully characterized using a combination of spectroscopic analyses, computational calculations, and single crystal X-ray diffraction. Rhomollone A (1) possesses an unprecedented 5/6/6/5 tetra-cyclic ring system (B-nor grayanane) incorporating a cyclopentene-1,3-dione scaffold. Rhodomollein XLIII (2) is a dimeric grayanoid, containing a novel 14-membered heterocyclic ring with a C ₂ symmetry axis. The antinociceptive activities of compounds 3, 4, 6, 7, and 12-17 were evaluated by an acetic acid-induced writhing test. Among them, compounds 3, 7,

SUBMITTER: Li Y 

PROVIDER: S-EPMC7332786 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature