Immunoinformatics study to search epitopes of spike glycoprotein from SARS-CoV-2 as potential vaccine.

ABSTRACT: The Coronavirus disease named COVID-19 is caused by the virus reported in 2019 first identified in China. The cases of this disease have increased and as of June 1^st, 2020 there are more than 216 countries affected. Pharmacological treatments have been proposed based on the resemblance of the HIV virus. With regard to prevention there is no vaccine, thus, we proposed to explore the spike protein due to its presence on the viral surface, and it also contains the putative viral entry receptor as well as the fusion peptide (important in the genome release). In this work we have employed In Silico techniques such as immunoinformatics tools which permit the identification of potential immunogenic regions on the viral surface (spike glycoprotein). From these analyses, we identi

SUBMITTER: Lizbeth RG 

PROVIDER: S-EPMC7332869 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature