In silico identification of potential inhibitors from Cinnamon against main protease and spike glycoprotein of SARS CoV-2.

ABSTRACT: Cinnamon has been utilized to remedy a lot of afflictions of humans. Literary works illustrate that it possesses numerous biological activities. Our research study is intended to recognize the phyto-derived antiviral substances from Cinnamon against COVID-19 main protease enzyme and to understand the in silico molecular basis of its activity. In the present study, 48 isolates compounds from Cinnamon retrieved from the PubMed database, are subjected to docking analysis. Docking study was performed using Autodock vina and PyRx software. Afterwards, admetSAR, as well as DruLiTo servers, were used to investigate drug-likeness prophecy. Our study shows that the nine phytochemicals of Cinnamon are very likely against the main protease enzyme of COVID-19. Furthe

SUBMITTER: Prasanth DSNBK 

PROVIDER: S-EPMC7332870 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature