Hypoxia-related parameters during septic shock resuscitation: Pathophysiological determinants and potential clinical implications.

ABSTRACT:

Background

Assessment of tissue hypoxia at the bedside has yet to be translated into daily clinical practice in septic shock patients. Perfusion markers are surrogates of deeper physiological phenomena. Lactate-to-pyruvate ratio (LPR) and the ratio between veno-arterial PCO₂ difference and Ca-vO₂ (ΔPCO₂/Ca-vO₂) have been proposed as markers of tissue hypoxia, but they have not been compared in the clinical scenario. We studied acute septic shock patients under resuscitation. We wanted to evaluate the relationship of these hypoxia markers with clinical and biochemical markers of hypoperfusion during septic shock resuscitation.

Methods

Secondary analysis of a randomized controlled trial. Septic shock patients were randomized to fluid

SUBMITTER: Pavez N 

PROVIDER: S-EPMC7333100 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature