Serum immunoglobulin G N-glycome: a potential biomarker in endometrial cancer.

ABSTRACT:

Background

With the increase in incidence and mortality of endometrial cancer (EC), there is an urgent need to explore non-invasive strategies for identifying EC patients and facilitating risk stratification. The alteration of immunoglobulin G (IgG) N-glycome has been indicated in autoimmune diseases and several cancer types, demonstrating a significant association with disease pathogenesis and progression. However, little has been investigated in the IgG N-glycome of EC patients.

Methods

A total of 94 EC patients and 112 healthy females were recruited and sorted into an EC cohort and a control cohort. Serum samples were obtained from every participant, and IgG N-glycome profiling was conducted using ultra-performance liquid chromatography (UPLC).

Results

A total of 2

SUBMITTER: Lin S 

PROVIDER: S-EPMC7333120 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature