Pharmacological treatment of neuropsychiatric symptoms of dementia: a network meta-analysis protocol.

ABSTRACT:

Background

Neuropsychiatric symptoms (NPS) of dementia are a common issue in dementia patients which can lead to poor medical and functional outcomes. Pharmacological interventions are its treatment of choice. However, whether to use pharmacological treatments in this population and which drug should be preferred remain controversial. We therefore aimed to compare and rank pharmacological interventions for NPS according to their efficacy and acceptability profiles by quantifying information from randomized controlled trials (RCTs).

Methods

We will include all RCTs reported as double-blind and comparing one active drug with another or with placebo that compare cholinesterase inhibitors (ChEIs), N-methyl-D-aspartic acid (NMDA) receptor modulators, antipsychotics, antidepressan

SUBMITTER: Huang YY 

PROVIDER: S-EPMC7333122 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature