Presence of a 34-gene signature is a favorable prognostic marker in squamous non-small cell lung carcinoma.

ABSTRACT:

Background

The tumor immune microenvironment is a heterogeneous entity. Gene expression analysis allows us to perform comprehensive immunoprofiling and may assist in dissecting the different components of the immune infiltrate. As gene expression analysis also provides information regarding tumor cells, differences in interactions between the immune system and specific tumor characteristics can also be explored. This study aims to gain further insights in the composition of the tumor immune infiltrate and to correlate these components to histology and overall survival in non-small cell lung cancer (NSCLC).

Methods

Archival tissues from 530 early stage, resected NSCLC patients with annotated tumor and patient characteristics were analyzed using the NanoString nCounter Analysi

SUBMITTER: Theelen WSME 

PROVIDER: S-EPMC7333331 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature