Efficacy and safety of tranexamic acid administration in traumatic brain injury patients: a systematic review and meta-analysis.

ABSTRACT:

Background

The exacerbation of intracranial bleeding is critical in traumatic brain injury (TBI) patients. Tranexamic acid (TXA) has been used to improve outcomes in TBI patient. However, the effectiveness of TXA treatment remains unclear. This study aimed to assess the effect of administration of TXA on clinical outcomes in patients with TBI by systematically reviewing the literature and synthesizing evidence of randomized controlled trials (RCTs).

Methods

MEDLINE, the Cochrane Central Register of Controlled Trials, and Igaku Chuo Zasshi (ICHUSHI) Web were searched. Selection criteria included randomized controlled trials with clinical outcomes of adult TBI patients administered TXA or placebo within 24 h after admission. Two investigators independently screened citations a

SUBMITTER: Yokobori S 

PROVIDER: S-EPMC7333334 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature