Highly blood perfused, highly metabolically active pancreatic islets may be more susceptible for immune attack.

ABSTRACT: Differences in pancreatic islet susceptibility during type 1 diabetes development may be explained by interislet variations. This study aimed to investigate if heterogeneities in vascular support and metabolic activity in rat and human islets may explain why some islets are attacked earlier than other islets. In rats, highly blood perfused islets were identified by injection of microspheres into the ascending aorta, whereas a combination of anterograde and retrograde injections of microspheres into pancreas was used to determine the islet vascular drainage system. Highly blood perfused islets had superior function and lower glucose threshold for insulin release when compared with other islets. These islets had a preferential direct venous drainage to the portal vein, whereas other islets m

SUBMITTER: Ullsten S 

PROVIDER: S-EPMC7333349 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature