NTCP gene polymorphisms and hepatitis B virus infection status in a Ghanaian population.

ABSTRACT:

Background

SLC10A1 gene codes NTCP, a receptor through which the hepatitis B virus (HBV) gets access into hepatocytes - a stage of the viral cycle necessary for replication. Polymorphism variants of SLC10A1 play roles in HBV infection, viral clearance, treatment outcome, and complications, in diverse ethnic groups and countries. However, no such study has been conducted in the Ghanaian population, a country with HBV endemicity. Therefore, an exploratory study was conducted to investigate the presence of three (3) single nucleotide polymorphisms (SNPs) in the SLC10A1 gene (rs2296651, rs61745930, and rs4646287) and assessed the risk of HBV infection among the Ghanaian population.

Method

Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was us

SUBMITTER: Nyarko E 

PROVIDER: S-EPMC7333392 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature