Unknown

Dataset Information

0

Distinct Target-Specific Mechanisms Homeostatically Stabilize Transmission at Pre- and Post-synaptic Compartments.


ABSTRACT: Neurons must establish and stabilize connections made with diverse targets, each with distinct demands and functional characteristics. At Drosophila neuromuscular junctions (NMJs), synaptic strength remains stable in a manipulation that simultaneously induces hypo-innervation on one target and hyper-innervation on the other. However, the expression mechanisms that achieve this exquisite target-specific homeostatic control remain enigmatic. Here, we identify the distinct target-specific homeostatic expression mechanisms. On the hypo-innervated target, an increase in postsynaptic glutamate receptor (GluR) abundance is sufficient to compensate for reduced innervation, without any apparent presynaptic adaptations. In contrast, a target-specific reduction in presynaptic neurotransmitter release probability is reflected by a decrease in active zone components restricted to terminals of hyper-innervated targets. Finally, loss of postsynaptic GluRs on one target induces a compartmentalized, homeostatic enhancement of presynaptic neurotransmitter release called presynaptic homeostatic potentiation (PHP) that can be precisely balanced with the adaptations required for both hypo- and hyper-innervation to maintain stable synaptic strength. Thus, distinct anterograde and retrograde signaling systems operate at pre- and post-synaptic compartments to enable target-specific, homeostatic control of neurotransmission.

SUBMITTER: Goel P 

PROVIDER: S-EPMC7333441 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

altmetric image

Publications

Distinct Target-Specific Mechanisms Homeostatically Stabilize Transmission at Pre- and Post-synaptic Compartments.

Goel Pragya P   Nishimura Samantha S   Chetlapalli Karthik K   Li Xiling X   Chen Catherine C   Dickman Dion D  

Frontiers in cellular neuroscience 20200626


Neurons must establish and stabilize connections made with diverse targets, each with distinct demands and functional characteristics. At <i>Drosophila</i> neuromuscular junctions (NMJs), synaptic strength remains stable in a manipulation that simultaneously induces hypo-innervation on one target and hyper-innervation on the other. However, the expression mechanisms that achieve this exquisite target-specific homeostatic control remain enigmatic. Here, we identify the distinct target-specific ho  ...[more]

Similar Datasets

| S-EPMC6070337 | biostudies-literature
| S-EPMC9179517 | biostudies-literature
| S-EPMC8550753 | biostudies-literature
| S-EPMC3362398 | biostudies-literature
| S-EPMC3823620 | biostudies-literature
| S-EPMC6250423 | biostudies-literature
| S-EPMC10368422 | biostudies-literature
| S-EPMC6405243 | biostudies-literature
| S-EPMC5300960 | biostudies-literature
| S-EPMC6258692 | biostudies-literature