Sex-Related Reserve Hypothesis in Alzheimer's Disease: Changes in Cortical Thickness with a Five-Year Longitudinal Follow-Up.

ABSTRACT:

Background

Sex effects on the progression of Alzheimer's disease (AD) have received less attention than other demographic factors, including onset age and education.

Objective

The aim of this study was to investigate whether sex affected cortical thinning in the disease progression of AD.

Methods

We prospectively recruited 36 patients with early-stage AD and 14 people with normal cognition. All subjects were assessed with magnetic resonance imaging at baseline, Year 1, Year 3, and Year 5. We performed cortical thickness analyses using surface-based morphometry on magnetic resonance imaging.

Results

Women with AD showed more rapid cortical thinning in the left dorsolateral frontal cortex, left superior temporal gyrus, bilateral temporo-parietal association corti

SUBMITTER: Lee J 

PROVIDER: S-EPMC7333738 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature