Non-genetic biomarkers and colorectal cancer risk: Umbrella review and evidence triangulation.

ABSTRACT: Several associations between non-genetic biomarkers and colorectal cancer (CRC) risk have been detected, but the strength of evidence and the direction of associations are not confirmed. We aimed to evaluate the evidence of these associations and integrate results from different approaches to assess causal inference. We searched Medline and Embase for meta-analyses of observational studies, meta-analyses of randomized clinical trials (RCTs), and Mendelian randomization (MR) studies measuring the associations between non-genetic biomarkers and CRC risk and meta-analyses of RCTs on supplementary micronutrients. We repeated the meta-analyses using random-effects models and categorized the evidence based on predefined criteria. We described each MR study and evaluated their credibility. Sevent

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7333850 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature