Cardiovascular phenotype and prognosis of patients with heart failure induced by cancer therapy.

ABSTRACT:

Objective

This study compared the clinical features, cardiac structure and function evaluated by echocardiography, cardiopulmonary response to exercise and long-term clinical outcomes between patients with heart failure (HF) induced by cancer therapy (CTHF) and heart failure not induced by cancer therapy (NCTHF).

Methods

We evaluated 75 patients with CTHF and 894 with NCTHF who underwent clinically indicated cardiopulmonary exercise testing, and followed these individuals for a median of 4.5 (3.0-5.8) years, during which 187 deaths and 256 composite events (death, heart transplantation and left ventricular (LV) assistant device implantation) occurred.

Results

Compared with NCTHF, patients with CTHF were younger, with lower prevalence of cardiovascular comorbidities, h

SUBMITTER: Nadruz W 

PROVIDER: S-EPMC7333864 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature