Analysis of FOXO3 Gene Polymorphisms Associated with Human Longevity.

ABSTRACT: Next-generation DNA sequencing has ushered in a new era of genotype-phenotype comparisons that have the potential to elucidate the genetic nature of complex traits. Since such methods rely on short sequence reads and since the human genome is composed largely of repetitive DNA elements larger than these read lengths many results cannot be mapped and are discarded, thus eliminating a large portion of the genome from analysis. Discerning associations in complex traits, such as longevity, will require either longer read lengths or methods to address these sequence complexities. Whole genome analysis, such as Genome Wide Association Studies (GWAS), also suffers from the repetitive nature of the human genome, as there exist many gaps in the availability of useable genetic markers, often in inte

SUBMITTER: Donlon TA 

PROVIDER: S-EPMC7334034 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature