T-Cell Infiltration and Adaptive Treg Resistance in Response to Androgen Deprivation With or Without Vaccination in Localized Prostate Cancer.

ABSTRACT:

Purpose

Previous studies suggest that androgen deprivation therapy (ADT) promotes antitumor immunity in prostate cancer. Whether a vaccine-based approach can augment this effect remains unknown.

Patients and methods

We conducted a neoadjuvant, randomized study to quantify the immunologic effects of a GM-CSF-secreting allogeneic cellular vaccine in combination with low-dose cyclophosphamide (Cy/GVAX) followed by degarelix versus degarelix alone in patients with high-risk localized prostate adenocarcinoma who were planned for radical prostatectomy.

Results

Both Cy/GVAX plus degarelix and degarelix alone led to significant increases in intratumoral CD8⁺ T-cell infiltration and PD-L1 expression as compared with a cohort of untreated, matched controls. However,

SUBMITTER: Obradovic AZ 

PROVIDER: S-EPMC7334055 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature