Associations between Genetically Predicted Blood Protein Biomarkers and Pancreatic Cancer Risk.

ABSTRACT:

Background

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with few known risk factors and biomarkers. Several blood protein biomarkers have been linked to PDAC in previous studies, but these studies have assessed only a limited number of biomarkers, usually in small samples. In this study, we evaluated associations of circulating protein levels and PDAC risk using genetic instruments.

Methods

To identify novel circulating protein biomarkers of PDAC, we studied 8,280 cases and 6,728 controls of European descent from the Pancreatic Cancer Cohort Consortium and the Pancreatic Cancer Case-Control Consortium, using genetic instruments of protein quantitative trait loci.

Results

We observed associations between predicted concentrations of 38

SUBMITTER: Zhu J 

PROVIDER: S-EPMC7334065 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature