Serum Concentrations of Emerging Vitamin D Biomarkers and Detection of Prevalent High-Risk HPV Infection in Mid-adult Women.

ABSTRACT:

Background

Vitamin D has potential immunomodulating benefits in infection. One prior population-based cross-sectional study showed a protective association between serum concentrations of 25(OH)D and high-risk human papillomavirus (hrHPV) detection. Additional biomarkers present at different stages along the vitamin D metabolic pathway may more completely characterize vitamin D status but have not yet been evaluated in relation to hrHPV infection.

Methods

Stored sera from women aged 30-50 years (N = 404) enrolled in an HPV natural history study from 2011-2012 were tested for 25(OH)D and 4 novel vitamin D biomarkers: 1,25(OH)₂D, 24,24(OH)₂D₃, free vitamin D, and vitamin D-binding protein. Cross-sectional associations between vitamin D s

SUBMITTER: Troja C 

PROVIDER: S-EPMC7334072 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature