ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction.

ABSTRACT:

Rationale

ZO-1 (Zona occludens 1), encoded by the tight junction protein 1 (TJP1) gene, is a regulator of paracellular permeability in epithelia and endothelia. ZO-1 interacts with the actin cytoskeleton, gap, and adherens junction proteins and localizes to intercalated discs in cardiomyocytes. However, the contribution of ZO-1 to cardiac physiology remains poorly defined.

Objective

We aim to determine the role of ZO-1 in cardiac function.

Methods and results

Inducible cardiomyocyte-specific Tjp1 deletion mice (Tjp1^fl/fl; Myh6^Cre/Esr1*) were generated by crossing the Tjp1 floxed mice and Myh6^Cre/Esr1* transgenic mice. Tamoxifen-induced loss of ZO-1 led to atrioventricular (

SUBMITTER: Dai W 

PROVIDER: S-EPMC7334106 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature