Comparison of ⁶⁸Ga-PSMA-617 PET/CT with mpMRI for the detection of PCa in patients with a PSA level of 4-20 ng/ml before the initial biopsy.

ABSTRACT: The study was aimed at assessing the diagnostic performance of ⁶⁸Ga-PSMA-617 PET/CT in the detection of prostate cancer (PCa) in patients with a prostate-specific antigen (PSA) level of 4-20 ng/ml and to compare its efficacy with that of multiparametric MRI (mpMRI). We analyzed the data of 67 consecutive patients with PSA levels of 4-20 ng/ml who almost simultaneously underwent ⁶⁸Ga-PSMA-617 PET/CT and mpMRI. ⁶⁸Ga-PSMA-617 PET/CT and mpMRI diagnostic performances were compared via receiver operating characteristic (ROC) curve analysis. Of the 67 suspected PCa cases, 33 had pathologically confirmed PCa. ⁶⁸Ga-PSMA-617 PET/CT showed a patient-based sensitivity, specificity, and positive and negative predictive values (PPVs and NPVs) of 87.88%, 88.24

SUBMITTER: Li Y 

PROVIDER: S-EPMC7334214 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature