Self-sustained planar intercalations due to mechanosignaling feedbacks lead to robust axis extension during morphogenesis.

ABSTRACT: Tissue elongation is a necessary process in metazoans to implement their body plans that is not fully understood. Here we propose a mechanism based on the interplay between cellular mechanics and primordia patterning that results in self-sustained planar intercalations. Thus, we show that a location-dependent modulation of the mechanical properties of cells leads to robust axis extension. To illustrate the plausibility of this mechanism, we test it against different patterning models by means of computer simulations of tissues where we implemented mechano-signaling feedbacks. Our results suggest that robust elongation relies on a trade-off between cellular and tissue strains that is orchestrated through the cleavage orientation. In the particular context of axis extension in Turing-pattern

SUBMITTER: Anbari S 

PROVIDER: S-EPMC7334228 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature