Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study.

ABSTRACT:

Purpose

The DIANA study aimed to evaluate how often antimicrobial de-escalation (ADE) of empirical treatment is performed in the intensive care unit (ICU) and to estimate the effect of ADE on clinical cure on day 7 following treatment initiation.

Methods

Adult ICU patients receiving empirical antimicrobial therapy for bacterial infection were studied in a prospective observational study from October 2016 until May 2018. ADE was defined as (1) discontinuation of an antimicrobial in case of empirical combination therapy or (2) replacement of an antimicrobial with the intention to narrow the antimicrobial spectrum, within the first 3 days of therapy. Inverse probability (IP) weighting was used to account for time-varying confounding when estimating the effect of ADE on clinical

SUBMITTER: De Bus L 

PROVIDER: S-EPMC7334278 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature