Comparing the regeneration potential between PLLA/Aragonite and PLLA/Vaterite pearl composite scaffolds in rabbit radius segmental bone defects.

ABSTRACT: Mussel-derived nacre and pearl, which are natural composites composed CaCO₃ platelets and interplatelet organic matrix, have recently gained interest due to their osteogenic potential. The crystal form of CaCO₃ could be either aragonite or vaterite depending on the characteristics of mineralization template within pearls. So far, little attention has been paid on the different osteogenic capacities between aragonite and vaterite pearl. In the current work, aragonite or vaterite pearl powders were incorporated into poly-l-lactic acid (PLLA) scaffold as bio-functional fillers for enhanced osteogenesis. In intro results revealed that PLLA/aragonite scaffold possessed stronger stimulatory effect on SaOS-2 cell proliferation and differentiation, evidenced by the enh

SUBMITTER: Huang Q 

PROVIDER: S-EPMC7334395 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature