Functional imaging evidence for task-induced deactivation and disconnection of a major default mode network hub in the mouse brain.

ABSTRACT: The default mode network (DMN) has been defined in functional brain imaging studies as a set of highly connected brain areas, which are active during wakeful rest and inactivated during task-based stimulation. DMN function is characteristically impaired in major neuropsychiatric diseases, emphasizing its interest for translational research. However, in the mouse, a major preclinical rodent model, there is still no functional imaging evidence supporting DMN deactivation and deconnection during high-demanding cognitive/sensory tasks. Here we have developed functional ultrasound (fUS) imaging to properly visualize both activation levels and functional connectivity patterns, in head-restrained awake and behaving mice, and investigated their modulation during a sensory-task, whisker stimulation

SUBMITTER: Ferrier J 

PROVIDER: S-EPMC7334502 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature