Prenatal exposure to nicotine disrupts synaptic network formation by inhibiting spontaneous correlated wave activity.

ABSTRACT: Correlated spontaneous activity propagating over a wide region of the central nervous system is expressed during a specific period of embryonic development. We previously demonstrated using an optical imaging technique with a voltage-sensitive dye that this wave-like activity, which we referred to as the depolarization wave, is fundamentally involved in the early process of synaptic network formation. We found that the in ovo application of bicuculline/strychnine or d-tubocurarine, which blocked the neurotransmitters mediating the wave, significantly reduced functional synaptic expression in the brainstem sensory nucleus. This result, particularly for d-tubocurarine, an antagonist of nicotinic acetylcholine receptors, suggested that prenatal nicotine exposure associate

SUBMITTER: Momose-Sato Y 

PROVIDER: S-EPMC7334560 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature