Network reorganisation following anterior temporal lobe resection and relation with post-surgery seizure relapse: A longitudinal study.

ABSTRACT:

Objective

To characterise temporal lobe epilepsy (TLE) surgery-induced changes in brain network properties, as measured using diffusion weighted MRI, and investigate their association with postoperative seizure-freedom.

Methods

For 48 patients who underwent anterior temporal lobe resection, diffusion weighted MRI was acquired pre-operatively, 3-4 months post-operatively (N = 48), and again 12 months post-operatively (N = 13). Data for 17 controls were also acquired over the same period. After registering all subjects to a common space, we performed two complementary analyses of the subjects' quantitative anisotropy (QA) maps. 1) A connectometry analysis which is sensitive to changes in subsections of fasciculi. 2) A graph theory approach which integrates connectivity informa

SUBMITTER: da Silva NM 

PROVIDER: S-EPMC7334605 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature