A Versatile Surface Bioengineering Strategy Based on Mussel-Inspired and Bioclickable Peptide Mimic.

ABSTRACT: In this work, we present a versatile surface engineering strategy by the combination of mussel adhesive peptide mimicking and bioorthogonal click chemistry. The main idea reflected in this work derived from a novel mussel-inspired peptide mimic with a bioclickable azide group (i.e., DOPA₄-azide). Similar to the adhesion mechanism of the mussel foot protein (i.e., covalent/noncovalent comediated surface adhesion), the bioinspired and bioclickable peptide mimic DOPA₄-azide enables stable binding on a broad range of materials, such as metallic, inorganic, and organic polymer substrates. In addition to the material universality, the azide residues of DOPA₄-azide are also capable of a specific conjugation of dibenzylcyclooctyne- (DBCO-) modified bioactive ligand

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC7334800 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature