Facets of individual-specific health signatures determined from longitudinal plasma proteome profiling.

ABSTRACT:

Background

Precision medicine approaches aim to tackle diseases on an individual level through molecular profiling. Despite the growing knowledge about diseases and the reported diversity of molecular phenotypes, the descriptions of human health on an individual level have been far less elaborate.

Methods

To provide insights into the longitudinal protein signatures of well-being, we profiled blood plasma collected over one year from 101 clinically healthy individuals using multiplexed antibody assays. After applying an antibody validation scheme, we utilized > 700 protein profiles for in-depth analyses of the individuals' short-term health trajectories.

Findings

We found signatures of circulating proteomes to be highly individual-specific. Considering technical and lo

SUBMITTER: Dodig-Crnkovic T 

PROVIDER: S-EPMC7334812 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature