Epigenomics and genotype-phenotype association analyses reveal conserved genetic architecture of complex traits in cattle and human.

ABSTRACT:

Background

Lack of comprehensive functional annotations across a wide range of tissues and cell types severely hinders the biological interpretations of phenotypic variation, adaptive evolution, and domestication in livestock. Here we used a combination of comparative epigenomics, genome-wide association study (GWAS), and selection signature analysis, to shed light on potential adaptive evolution in cattle.

Results

We cross-mapped 8 histone marks of 1300 samples from human to cattle, covering 178 unique tissues/cell types. By uniformly analyzing 723 RNA-seq and 40 whole genome bisulfite sequencing (WGBS) datasets in cattle, we validated that cross-mapped histone marks captured tissue-specific expression and methylation, reflecting tissue-relevant biology. Through integrating

SUBMITTER: Liu S 

PROVIDER: S-EPMC7334855 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature