Ontology highlight
ABSTRACT:
SUBMITTER: Diederichs KA
PROVIDER: S-EPMC7335169 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Diederichs Kathryn A KA Ni Xiaodan X Rollauer Sarah E SE Botos Istvan I Tan Xiaofeng X King Martin S MS Kunji Edmund R S ERS Jiang Jiansen J Buchanan Susan K SK
Nature communications 20200703 1
In mitochondria, β-barrel outer membrane proteins mediate protein import, metabolite transport, lipid transport, and biogenesis. The Sorting and Assembly Machinery (SAM) complex consists of three proteins that assemble as a 1:1:1 complex to fold β-barrel proteins and insert them into the mitochondrial outer membrane. We report cryoEM structures of the SAM complex from Myceliophthora thermophila, which show that Sam50 forms a 16-stranded transmembrane β-barrel with a single polypeptide-transport- ...[more]