Patterns and determinants of exhaled nitric oxide trajectories in schoolchildren over a 7-year period.

ABSTRACT: Fractional exhaled nitric oxide (F _ENO50 ), a marker of allergic airway inflammation, is used in respiratory research and asthma clinical care; however, its trajectory with increasing age during childhood has not been well characterised. We examined F _ENO50 longitudinally during a period of important somatic growth to describe trajectories across childhood and adolescence in healthy participants and evaluate clinical factors as potential determinants of trajectories.F _ENO50 was collected at six visits over 8 years in a population-based cohort of 1791 schoolchildren without asthma (median age at entry 8.4 years). Smooth sex-specific F _ENO50 trajectories were estimated using ge

SUBMITTER: Garcia E 

PROVIDER: S-EPMC7335353 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature