Ontology highlight
ABSTRACT:
SUBMITTER: McHugh D
PROVIDER: S-EPMC7335381 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Life science alliance 20200623 8
HIV and EBV are human pathogens that cause a considerable burden to worldwide health. In combination, these viruses are linked to AIDS-associated lymphomas. We found that EBV, which transforms B cells, renders them susceptible to HIV-1 infection in a CXCR4 and CD4-dependent manner in vitro and that CXCR4-tropic HIV-1 integrates into the genome of these B cells with the same molecular profile as in autologous CD4<sup>+</sup> T cells. In addition, we established a humanized mouse model to investig ...[more]