Early HIV infection is associated with reduced proportions of gamma delta T subsets as well as high creatinine and urea levels.

ABSTRACT: Renal dysfunctions are major predictors of co-morbidities and mortality in HIV-infected individuals. Unconventional T cells have been shown to regulate kidney functions. However, there is dearth of information on the effect of HIV-associated nephropathies on γδ and DN T cells. It is also not clear whether γδ T cell perturbations observed during the early stages of HIV infection occur before immune activation. In this study, we investigated the relationship between creatinine and urea on the number of unconventional T cells in HIV-infected individuals at the early and chronic stages of infection. Persons in the chronic stage of infection were divided into treatment naïve and exposed groups. Treatment exposed individuals were further subdivided into groups with undetectable and detectable HI

SUBMITTER: Olusola BA 

PROVIDER: S-EPMC7335456 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature