Helicobacter pylori Infection Impairs Endothelial Function Through an Exosome-Mediated Mechanism.

ABSTRACT: Background Epidemiological studies have suggested an association between Helicobacter pylori (H pylori) infection and atherosclerosis through undefined mechanisms. Endothelial dysfunction is critical to the development of atherosclerosis and related cardiovascular diseases. The present study was designed to test the hypothesis that H pylori infection impaires endothelial function through exosome-mediated mechanisms. Methods and Results Young male and female patients (18-35 years old) with and without H pylori infection were recruited to minimize the chance of potential risk factors for endothelial dysfunction for the study. Endothelium-dependent flow-mediated vasodilatation of the brachial artery was evaluated in the patients and control subjects. Mouse infectio

SUBMITTER: Xia X 

PROVIDER: S-EPMC7335532 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature